Tissue array for Tp53 , C-myc , CCND1 gene over-expression in different tumors
نویسندگان
چکیده
منابع مشابه
Evaluation of HER2, MDM2, MYC, MET and TP53 gene copy number alterations in gastric cancer patients
Background: Gastric cancer (GC) is considered as one of the most common types of cancer worldwide with poor prognosis and generally limited treatment options. Recent studies have indicated that HER2, MDM2, MYC, MET, and TP53 play an important role in the development of gastric cancer. Therefore, the aim of this study was to evaluate the incidence of amplification/deletion of these genes in pati...
متن کاملCorrelation of HER2, MDM2, c-MYC, c-MET, and TP53 Copy Number Alterations in Circulating Tumor Cells with Tissue in Gastric Cancer Patients: A Pilot Study
Background: The analysis of the gene copy number alterations in tumor samples are increasingly used for diagnostic and prognostic purposes in patients with gastric cancer (GC). However, these procedures are not always applicable due to their invasive nature. In this study, we have analyzed the copy number alterations of five genes (HER2, MDM2, c-MYC, c-MET, and TP53) with a fixed relevance for ...
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Activation of myc-family oncogenes has been implicated in the genesis of a variety of neoplasms. In addition, these genes exhibit specific patterns of expression during murine development. We now report that N- and c-myc are differentially expressed in normal developing human renal tissues and in Wilms' tumor, a neoplasm which derives from primitive kidney cells. Twelve of 13 Wilms' tumors test...
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We examined the expression of c-myc and mutations in the KRAS gene in ovarian mucinous tumors to explore the pathogenesis of these tumors and the feasibility of targeted gene therapy. Expression of c-myc protein and mutations in the KRAS gene in 24 cases of ovarian mucinous cystadenoma, 46 cases of ovarian borderline mucinous cystadenoma, and 46 cases of ovarian mucinous cystadenocarcinoma were...
متن کاملEnhanced expression of the c-myc gene in bovine leukemia virus-induced bovine tumors.
We have detected elevated levels of c-myc gene expression in neoplastic cells from all seven bovine leukemia virus (BLV)-induced bovine tumors examined, but not in BLV-infected, nonneoplastic lymphoid cells. No rearrangement or amplification of the c-myc gene could be demonstrated in any of the BLV-induced tumors. Furthermore, BLV proviral DNA was found to have no preferred site of integration ...
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ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2008
ISSN: 1007-9327
DOI: 10.3748/wjg.14.7199